RT Journal Article SR Electronic T1 Reduction in γ-Glutamyl Hydrolase Expression Is Associated with Response to Uracil and Tegafur/Leucovorin Chemotherapy in Patients with Colorectal Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 3431 OP 3438 VO 33 IS 8 A1 SOTARO SADAHIRO A1 TOSHIYUKI SUZUKI A1 AKIRA TANAKA A1 KAZUTAKE OKADA A1 AKEMI KAMIJO A1 HIDEKI NAGASE A1 JUNJI UCHIDA YR 2013 UL http://ar.iiarjournals.org/content/33/8/3431.abstract AB To identify the genes and clinical parameters associated with efficacy of uracil and tegafur/leucovorin (UFT/LV) chemotherapy in colorectal cancer (CRC), we compared the levels of reduced folate in tumors between patients receiving LV and those not receiving LV (study I), and explored the changes in the expression levels of 14 genes after two weeks of UFT/LV chemotherapy in 73 patients with CRC (study II). In study I, the reduced folate levels after LV administration were approximately 3-fold higher than those without LV administration in patients with right-sided tumors or aged >75 years old (p=0.019). In study II, the reduction in γ-glutamyl hydrolase (GGH) expression in responders and in patients with right-sided tumors or aged >75 years old was significantly greater than that in non-responders (p<0.001) and in other patients, respectively (p=0.003). Increase of reduced folate and reduction in GGH expression were associated with response to UFT/LV chemotherapy in patients with right-sided tumors or aged >75 years old.