RT Journal Article
SR Electronic
T1 Roles of ZFAT in Haematopoiesis, Angiogenesis and Cancer Development
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2833
OP 2837
VO 33
IS 7
A1 TOSHIYUKI TSUNODA
A1 SENJI SHIRASAWA
YR 2013
UL http://ar.iiarjournals.org/content/33/7/2833.abstract
AB A zinc-finger gene in autoimmune thyroid disease susceptibility region (ZFAT) was originally identified as a highly conserved immune-related transcriptional regulator containing one adenosine-thymidine (AT)-hook and 18 C2H2-type zinc-finger domains. Subsequently, roles of ZFAT in development, primitive haematopoiesis, angiogenesis, immune responses and several common diseases, such as multiple sclerosis, hypertension and cancer, have been demonstrated. Previously, we recorded a ZFAT protein expression in MOLT-4 human acute T-lymphoblastic leukaemia cells, while ZFAT knockdown activated caspases and induced apoptosis in these cells. Hence, the precise functions of ZFAT are of particular interest in cancer research. In this article, we have reviewed investigations on the roles of ZFAT in haematopoietic and angiogenesis, and discussed the possible involvement of ZFAT in haematopoietic malignancies.