RT Journal Article
SR Electronic
T1 Tumor-targeted Photodynamic Therapy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2823
OP 2831
VO 33
IS 7
A1 NAOTO SHIRASU
A1 SUNG OUK NAM
A1 MASAHIDE KUROKI
YR 2013
UL http://ar.iiarjournals.org/content/33/7/2823.abstract
AB Photodynamic therapy (PDT) is a well-established clinical treatment modality for various diseases, including cancer. It involves the topical or systemic administration of a photosensitizer, followed by selective irradiation of the target lesion with a specific wavelength of non-ionizing light, which triggers oxidative photodamage and subsequent death of the targeted cells. Due to this two-step therapeutic process, PDT is a safe and minimally-invasive therapy. Nevertheless, classical non-targeted photosensitizers lack sufficient tumor selectivity and are taken up in the neighboring normal tissues, resulting in undesirable adverse effects. To overcome this obstacle, diverse tumor-targeting approaches have been developed. In this article, we discuss the current strategies and rationale regarding tumor-targeted PDT.