TY - JOUR T1 - Correlation of Immunohistopathological Expression of Somatostatin Receptor-2 in Breast Cancer and Tumor Detection with <sup>68</sup>Ga-DOTATOC and 18F-FDG PET Imaging in an Animal Model JF - Anticancer Research JO - Anticancer Res SP - 3015 LP - 3019 VL - 33 IS - 8 AU - ELISABETH CHEREAU AU - LUCILE DURAND AU - ALBANE FRATI AU - AURELIE PRIGNON AU - JEAN-NOËL TALBOT AU - ROMAN ROUZIER Y1 - 2013/08/01 UR - http://ar.iiarjournals.org/content/33/8/3015.abstract N2 - Background: Fludeoxyglucose positron emission topography (18F-FDG PET) is insufficiently sensitive at detecting small or low-grade breast tumors. The characterization of somatostatin receptors (SSTR) in tumors and the development of 68Ga-DOTATOC PET for imaging could be of interest. The aim of this study was to validate an animal model expressing SSTR2 and to correlate the immunohistochemical (IHC) analysis with 18F-FDG and 68Ga-DOTATOC uptake in vivo. Materials and Methods: Ten nude mice were xenografted with the ZR-75-1 breast tumor cell line. Imaging was performed with 68Ga-DOTATOC and 18F-FDG and correlated to IHC analysis of SSTR2. Results: IHC analyses showed that the tumors expressed SSTR2. On PET imaging, the tumors were barely visible with 18F-FDG, whereas with 68Ga-DOTATOC, specific two-fold higher uptake was observed (p&lt;0.005). Conclusion: Our results suggest that 68Ga-DOTATOC PET could be used for detection of breast tumors not detected with 18F-FDG. SSTR2 status should be assessed to allow for individual treatment. ER -