RT Journal Article SR Electronic T1 Correlation of Immunohistopathological Expression of Somatostatin Receptor-2 in Breast Cancer and Tumor Detection with 68Ga-DOTATOC and 18F-FDG PET Imaging in an Animal Model JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 3015 OP 3019 VO 33 IS 8 A1 ELISABETH CHEREAU A1 LUCILE DURAND A1 ALBANE FRATI A1 AURELIE PRIGNON A1 JEAN-NOËL TALBOT A1 ROMAN ROUZIER YR 2013 UL http://ar.iiarjournals.org/content/33/8/3015.abstract AB Background: Fludeoxyglucose positron emission topography (18F-FDG PET) is insufficiently sensitive at detecting small or low-grade breast tumors. The characterization of somatostatin receptors (SSTR) in tumors and the development of 68Ga-DOTATOC PET for imaging could be of interest. The aim of this study was to validate an animal model expressing SSTR2 and to correlate the immunohistochemical (IHC) analysis with 18F-FDG and 68Ga-DOTATOC uptake in vivo. Materials and Methods: Ten nude mice were xenografted with the ZR-75-1 breast tumor cell line. Imaging was performed with 68Ga-DOTATOC and 18F-FDG and correlated to IHC analysis of SSTR2. Results: IHC analyses showed that the tumors expressed SSTR2. On PET imaging, the tumors were barely visible with 18F-FDG, whereas with 68Ga-DOTATOC, specific two-fold higher uptake was observed (p<0.005). Conclusion: Our results suggest that 68Ga-DOTATOC PET could be used for detection of breast tumors not detected with 18F-FDG. SSTR2 status should be assessed to allow for individual treatment.