PT - JOURNAL ARTICLE AU - KOICHIRO HARUKI AU - HIROAKI SHIBA AU - YUKI FUJIWARA AU - KENEI FURUKAWA AU - SHIGEKI WAKIYAMA AU - MASAICHI OGAWA AU - YUICHI ISHIDA AU - TAKEYUKI MISAWA AU - KATSUHIKO YANAGA TI - Negative Impact of Surgical Site Infection on Long-term Outcomes after Hepatic Resection for Colorectal Liver Metastases DP - 2013 Apr 01 TA - Anticancer Research PG - 1697--1703 VI - 33 IP - 4 4099 - http://ar.iiarjournals.org/content/33/4/1697.short 4100 - http://ar.iiarjournals.org/content/33/4/1697.full SO - Anticancer Res2013 Apr 01; 33 AB - Background: Postoperative infectious complications are associated with a poor long-term prognosis after resection of malignant tumors. We hypothesized that postoperative infectious complication such as surgical site infection (SSI) may have a negative impact on the outcome of elective hepatic resection for colorectal liver metastases (CRLM), and that the Glasgow prognostic score (GPS), which reflects the systemic inflammatory response, might predict for such complications. Patients and Methods: The subjects of the study were 77 patients who underwent hepatic resection for CRLM between January 2000 and December 2009. We retrospectively investigated the relation between SSI and disease-free, as well as overall, survival. Moreover, we assessed the risk factors pertinent to SSI. Results: In multivariate analysis, having more than four lymph node metastases (p=0.015) was a significant predictor of disease-free survival, while significant predictors of overall survival were the presence of more than four lymph node metastases (p=0.001) and SSI (p=0.008). Moreover, bilobar distribution (p=0.026), intraoperative fresh-frozen plasma transfusion (p=0.036) and GPS 1 or 2 (p=0.023) were found to be independent risk factors for SSI. Conclusion: Development of SSI after elective hepatic resection is associated with worse long-term outcomes in patients with CRLM. The GPS may be useful for preoperative risk stratification of SSI in such patients.