PT  - JOURNAL ARTICLE
AU  - MARÁZ, ANIKÓ
AU  - FURÁK, JÓZSEF
AU  - VARGA, ZOLTÁN
AU  - KAHÁN, ZSUZSANNA
AU  - TISZLAVICZ, LÁSZLÓ
AU  - HIDEGHÉTY, KATALIN
TI  - Thrombocytosis Has a Negative Prognostic Value in Lung Cancer
DP  - 2013 Apr 01
TA  - Anticancer Research
PG  - 1725--1729
VI  - 33
IP  - 4
4099  - http://ar.iiarjournals.org/content/33/4/1725.short
4100  - http://ar.iiarjournals.org/content/33/4/1725.full
SO  - Anticancer Res2013 Apr 01; 33
AB  - Background: Solid tumours have worse prognosis when associated with thrombocytosis. Our study assessed the prognostic value of thrombocytosis, and its relation with smoking habits in lung cancer. Patients and Methods: A total of 398 patients were operated on then divided into two groups, those with normal platelet counts (n=312), and those with thrombocytosis (n=86); 348 out of 398 patients had data for smoking habits (99 non-smokers, 249 smokers). Results: The frequency of thrombocytosis was 18.6%, 19.3%, 27.5 and 28.6% in patients with tumor stages I to IV, respectively. Thrombocytosis appeared most frequently in patients with squamous cell lung cancer, and among smokers. The overall 5-year survival was worse in patients with thrombocytosis (p<0.001). By uni- and multivariate analyses, platelet count, and T and N status were found to be independent prognostic factors. Conclusion: Our study indicates that the presence of perioperative thrombocytosis in patients undergoing surgery should be considered as an independent prognostic factor of poor survival, and should be taken into account in regard to therapy.