RT Journal Article SR Electronic T1 Murine Double Minute 2 and Its Association with Chemoradioresistance of Esophageal Squamous Cell Carcinoma JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1463 OP 1471 VO 33 IS 4 A1 HIROSHI OKAMOTO A1 FUMIYOSHI FUJISHIMA A1 YASUHIRO NAKAMURA A1 MASASHI ZUGUCHI A1 GO MIYATA A1 TAKASHI KAMEI A1 TORU NAKANO A1 KAZUNORI KATSURA A1 SHIGEO ABE A1 YUSUKE TANIYAMA A1 JIN TESHIMA A1 MIKA WATANABE A1 AKIRA SATO A1 NORIAKI OHUCHI A1 HIRONOBU SASANO YR 2013 UL http://ar.iiarjournals.org/content/33/4/1463.abstract AB Background: Definitive chemoradiotherapy (dCRT) has been established as the standard treatment for esophageal squamous cell carcinoma (ESCC). However, many patients develop persistent or recurrent disease following dCRT. We investigated factors related to chemoradioresistance and treatment outcomes in patients with ESCC who underwent salvage esophagectomy after dCRT. Patients and Methods: We selected 38 patients with persistent disease and 24 with recurrent disease who underwent salvage esophagectomy after dCRT, immunolocalized p53, p16, p27, murine double minute 2 (MDM2), cyclin D1, Ki-67, and epidermal growth factor receptor, and correlated the findings with clinicopathological features. Results: MDM2 positivity was significantly higher among patients with persistent disease than among those with recurrent disease (p<0.0001). In addition, negative p16 expression was a predictor of poor prognosis among patients with persistent disease. Conclusion: MDM2 overexpression plays an important role in chemoradioresistance of ESCC; furthermore, negative p16 expression can predict poor prognosis of patients with persistent disease.