TY - JOUR T1 - Aryl Hydrocarbon Receptor and Lung Cancer JF - Anticancer Research JO - Anticancer Res SP - 1247 LP - 1256 VL - 33 IS - 4 AU - JUNCHIEH J. TSAY AU - KAM-MENG TCHOU-WONG AU - ALISSA K. GREENBERG AU - HARVEY PASS AU - WILLIAM N. ROM Y1 - 2013/04/01 UR - http://ar.iiarjournals.org/content/33/4/1247.abstract N2 - The leading cause of lung cancer is exposure to cigarette smoke and other environmental pollutants, which include formaldehyde, acrolein, benzene, dioxin, and polycyclic aromatic hydrocarbons (PAHs). PAHs and dioxins are exogenous ligands that directly bind to the aryl hydrocarbon receptor (AhR), a transcription factor that activates xenobiotic metabolism, histone modification (an important step in DNA methylation) and, ultimately, tumorigenesis. In this review article we summarize the current understanding of AhR and its role in the development of lung cancer, including its influence on cell proliferation, angiogenesis, inflammation, and apoptosis. ER -