PT  - JOURNAL ARTICLE
AU  - JUNCHIEH J. TSAY
AU  - KAM-MENG TCHOU-WONG
AU  - ALISSA K. GREENBERG
AU  - HARVEY PASS
AU  - WILLIAM N. ROM
TI  - Aryl Hydrocarbon Receptor and Lung Cancer
DP  - 2013 Apr 01
TA  - Anticancer Research
PG  - 1247--1256
VI  - 33
IP  - 4
4099  - http://ar.iiarjournals.org/content/33/4/1247.short
4100  - http://ar.iiarjournals.org/content/33/4/1247.full
SO  - Anticancer Res2013 Apr 01; 33
AB  - The leading cause of lung cancer is exposure to cigarette smoke and other environmental pollutants, which include formaldehyde, acrolein, benzene, dioxin, and polycyclic aromatic hydrocarbons (PAHs). PAHs and dioxins are exogenous ligands that directly bind to the aryl hydrocarbon receptor (AhR), a transcription factor that activates xenobiotic metabolism, histone modification (an important step in DNA methylation) and, ultimately, tumorigenesis. In this review article we summarize the current understanding of AhR and its role in the development of lung cancer, including its influence on cell proliferation, angiogenesis, inflammation, and apoptosis.