PT  - JOURNAL ARTICLE
AU  - NAKAYAMA, HIDETSUGU
AU  - KANEMOTO, AYAE
AU  - KIKUCHI, KOJI
AU  - MATSUKI, KATSUYUKI
AU  - TOMOBE, MITSURO
AU  - TSUKAMOTO, SADAMU
AU  - TAKESHIMA, HITOSHI
AU  - OSHIRO, YOSHIKO
AU  - SUGAHARA, SHINJI
AU  - TOKUUYE, KOICHI
TI  - Delayed Radiotherapy for Patients with Localized Prostate Cancer: Validation by Propensity Score Matching
DP  - 2013 Apr 01
TA  - Anticancer Research
PG  - 1629--1633
VI  - 33
IP  - 4
4099  - http://ar.iiarjournals.org/content/33/4/1629.short
4100  - http://ar.iiarjournals.org/content/33/4/1629.full
SO  - Anticancer Res2013 Apr 01; 33
AB  - Aim: To retrospectively investigate the biochemical outcome following delayed radiotherapy in patients with prostate cancer. Patients and Methods: From July 2000 to November 2008, 144 consecutive patients with localized prostate cancer underwent radiotherapy and androgen-deprivation therapy. Biochemical progression-free survival was compared in patients who began radiotherapy >6 months (delayed group) with these who began ≤6 months (non-delayed group) from diagnosis by biopsy. Treatment selection bias was adjusted by the propensity score method. Results: After a median follow-up of 64 months, the 5-year biochemical progression-free survival of the delayed and non-delayed groups was 87.4% (95% confidence interval, CI=69.7-95.1%) and 96.6% (95% CI=89.6-98.9%), respectively (p=0.03). Delayed radiotherapy was the only independent risk factor for biochemical progression (hazard ratio=3.97, 95% CI 1.07-14.7, p=0.04). The results were validated by propensity score analysis. Conclusion: Delaying radiotherapy by >6 months increases the risk of biochemical progression in patients with localized prostate cancer.