TY - JOUR T1 - Lateral Lymph-node Dissection for Rectal Cancer: Meta-analysis of all 944 Cases Undergoing Surgery During 1975-2004 JF - Anticancer Research JO - Anticancer Res SP - 2921 LP - 2927 VL - 33 IS - 7 AU - TETSUSHI KINUGASA AU - YOSHITO AKAGI AU - TAKAFUMI OCHI AU - YOSHIAKI ISHIBASHI AU - NATSUKI TANAKA AU - YOUSUKE OKA AU - TOMOAKI MIZOBE AU - KOUTAROU YUGE AU - SHINYA FUJINO AU - SHIROU KIBE AU - KAZUO SHIROUZU Y1 - 2013/07/01 UR - http://ar.iiarjournals.org/content/33/7/2921.abstract N2 - Background: Colorectal cancer is the third most common cancer and leading cause of cancer-related death in Japan. One of the major problems in rectal cancer surgery is local recurrence. Pelvic sidewall dissection (PSD) has the potential to reduce local recurrence. Patients and Methods: This study included all 994 patients with rectal cancer who underwent curative surgery from January 1975 until December 2004, at the Kurume University Hospital in Fukuoka, Japan. The patients were analyzed to determine whether lateral lymph node (LLN) metastasis correlates with clinicopathological factors, and to determine a diagnostic tool based on magnetic resonance imaging (MRI) findings. Results: The rate of positive LLNs in patients who underwent PSD was 7.5% in the upper rectum, and 14.5% in the lower rectum. Logistic regression analysis disclosed that perirectal lymph nodes metastasis was associated with an increased incidence of positive LLNs and had a greater hazard ratio. Positive LLNs were frequently found to be located along the internal iliac artery (47 patients; 89%) or around the oburator vessels and nerve (17 patients; 32%). MRI has become a promising diagnostic tool in patients with rectal cancer including LLN estimation. Conclusion: We speculate that PSD may be a good candidate as an effective strategy for lower rectal cancer. In further studies, it is important to investigate the validity of PSD for its potential clinical use in lower rectal cancer therapy and prognosis. ER -