TY - JOUR T1 - IGF-IEc Expression Is Associated with Advanced Clinical and Pathological Stage of Prostate Cancer JF - Anticancer Research JO - Anticancer Res SP - 2441 LP - 2445 VL - 33 IS - 6 AU - ARGYRO SAVVANI AU - CONSTANTINA PETRAKI AU - PAVLOS MSAOUEL AU - EVANGELIA DIAMANTI AU - IOANNIS XOXAKOS AU - MICHAEL KOUTSILIERIS Y1 - 2013/06/01 UR - http://ar.iiarjournals.org/content/33/6/2441.abstract N2 - Background: Recent evidence suggests a role for the insulin-like growth factor-1Ec (IGF-IEc) transcript variant in cancer biology. The aim of the present study was to investigate whether IGF-IEc expression is associated with prostate cancer stage. Materials and Methods: Formalin-fixed and paraffin-embedded prostate cancer surgical specimens from 83 patients were assessed by immunohistochemistry for IGF-IEc expression. Results: Normal prostate epithelium was negative or demonstrated mild IGF-IEc cytoplasmic expression whereas prostate cancer exhibited mild to strong cytoplasmic immunoexpression. The mean IGF-1Ec expression, was significantly lower (p=0.004) in localized (stage ≤IIb) prostate cancer, compared to locally advanced tumors (stage ≥III). Only one out of 83 (1.2%) prostate cancer samples was completely negative for IGF-IEc. A weak-positive correlation was also observed between IGF-IEc expression levels and Gleason score (r=0.247; p=0.024). Conclusion: The present data demonstrate that the expression of IGF-IEc is positively-associated with more advanced stage and higher Gleason score of prostate carcinomas. ER -