TY - JOUR T1 - <sup>18</sup>F-FDG-PET/CT in Potentially Advanced Renal Cell Carcinoma: A Role in Treatment Decisions and Prognosis Estimation JF - Anticancer Research JO - Anticancer Res SP - 2665 LP - 2672 VL - 33 IS - 6 AU - JIRI FERDA AU - EVA FERDOVA AU - MILAN HORA AU - ONDREJ HES AU - JINDRICH FINEK AU - ONDREJ TOPOLCAN AU - BORIS KREUZBERG Y1 - 2013/06/01 UR - http://ar.iiarjournals.org/content/33/6/2665.abstract N2 - Aim: to assess the influence of positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (18F-FDG-PET/CT) on the treatment decision in renal cell carcinoma and to assess the prognostic value of the 18F-FDG accumulation assessments. Patients and Methods: Data from 60 patients were included. The cohort consisted of 43 males, 17 females, mean age 66.2 years (range=49-86 years). All patients underwent 18F-FDG-PET/CT including two-phase CT-angiography of the kidneys. Locally advanced or generalized renal cell carcinoma was suspected in all patients. The level of the 18F-FDG accumulation within the tumor was compared with the histological grading and the development of the disease was assessed 12 months after 18F-FDG-PET/CT. Results: Overall mortality reached 46.7%, the highest 18F-FDG accumulation showed tumor of grade 4 (mean SUVmax=10.7, range=5-23), the highest mortality was found for tumors exceeding SUVmax value of 10 (mortality 62.5%). New information was brought by 18F-FDG-PET/CT in 85% of cases. Conclusion: 18F-FDG-PET/CT has the potential to estimate the patient's survival according to the 18F-FDG accumulation measured in SUVmax. Depiction of occult metastatic disease has an emerging role in decision making regarding surgery. ER -