@article {FERRO2707, author = {PAOLA FERRO and PIER ALDO CANESSA and ENRICO BATTOLLA and PAOLO DESSANTI and MARIA CRISTIANA FRANCESCHINI and LUIGI CHIAFFI and ANNA MORABITO and VINCENZO FONTANA and RICCARDO PEZZI and FRANCO FEDELI and MARIA PIA PISTILLO and SILVIO RONCELLA}, title = {Mesothelin Is More Useful in Pleural Effusion than in Serum in the Diagnosis of Pleural Mesothelioma}, volume = {33}, number = {6}, pages = {2707--2713}, year = {2013}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Soluble mesothelin-related peptide (SMRP) is regarded as a biomarker of malignant pleural mesothelioma (MPM). Herein, we compared the diagnostic performances of SMRP in matched pleural effusion (PE-SMRP) and serum (S-SMRP). Materials and Methods: Diagnosis on pleural biopsies was performed for all patients including 43 with MPM, 23 with non-MPM pleural metastases (MTS) and 36 with benign (BNG) pleural diseases. SMRP was measured by a MesoMark ELISA (Cis-Bio International Gif/Yvette; France). Results: Using the receiver operating characteristic (ROC) analysis, 12.70 and 1.08 nM were detected as cut-off values to optimal discrimination for PE-SMRP and S-SMRP, respectively. PE-SMRP showed a better diagnostic accuracy than S-SMRP in MPM vs. MTS+BNG (area under the ROC curve=81.6 vs. 70.5; sensitivity=69.8\% vs. 46.5\%; specificity=88.1\% vs. 84.7\%; diagnostic odds ratio (DOR)=17.1 vs. 4.8). In S-SMRP-negative patients, PE-SMRP maintained an acceptable performance (Sensitivity=47.8\%; DOR=8.3; p=0.001), whereas in PE-SMRP-negative patients, S-SMRP performed very poorly (Sensitivity=15.4\%; DOR=1.2; p=0.858). Conclusion: PE-SMRP detection has a superior diagnostic accuracy than S-SMRP detection in the diagnosis of MPM.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/33/6/2707}, eprint = {https://ar.iiarjournals.org/content/33/6/2707.full.pdf}, journal = {Anticancer Research} }