TY - JOUR T1 - Hydrogen Peroxide Enhances Radiation-induced Apoptosis and Inhibition of Melanoma Cell Proliferation JF - Anticancer Research JO - Anticancer Res SP - 1799 LP - 1807 VL - 33 IS - 5 AU - YUJIANG FANG AU - BRADLEY J. MOORE AU - QIAN BAI AU - KATHRYN M. COOK AU - ELIZABETH J. HERRICK AU - MICHAEL B. NICHOLL Y1 - 2013/05/01 UR - http://ar.iiarjournals.org/content/33/5/1799.abstract N2 - The efficacy of radiation therapy (RT) for melanoma is limited in part by its radioresistance. Here, we examined the radiosensitizing effect of hydrogen peroxide (H2O2) on a radioresistant melanoma cell line, HTB-65. We found that H2O2 synergized with RT to inhibit melanoma cell proliferation and promote apoptosis. The antiproliferative effect of H2O2/RT correlated with increased expression of p15 and reduced expression of cyclin D, cyclin E, cyclin-dependent kinase (CDK)2 and CDK4. The pro-apoptotic effect of H2O2 /RT correlated with reduced expression of the B-cell CLL/lymphoma (BCL)2. These data highlight the potential of H2O2 as a radiation sensitizer for melanoma treatment and show that this warrants further study. ER -