RT Journal Article
SR Electronic
T1 The Role of Completion Surgery After Concurrent Radiochemotherapy in Locally Advanced Stages IB2-IIB Cervical Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1661
OP 1666
VO 33
IS 4
A1 ELISABETH CHEREAU
A1 CLAIRE DE LA HOSSERAYE
A1 MARCOS BALLESTER
A1 LAURIE MONNIER
A1 ROMAN ROUZIER
A1 EMMANUEL TOUBOUL
A1 EMILE DARAÏ
YR 2013
UL http://ar.iiarjournals.org/content/33/4/1661.abstract
AB Background: The gold standard for treating patients with locally advanced stages of cervical cancer is concurrent radiochemotherapy (CRT), but recent studies have failed to demonstrate the effect of completion surgery on survival. The aim of this study was to evaluate the role of completion surgery in stage IB2-IIB cervical cancer. Patients and Methods: From 2002 to 2012, 80 women (stage IB2-IIB disease) underwent a pre-therapeutic pelvic and para-aortic lymphadenectomy associated with CRT. Results: Forty-six patients (57.5%) underwent completion surgery. Multivariate analysis identified pelvic lymph node status as a predictive factor for completion surgery (p<0.001) and histological type for tumor residue (p=0.04). In multivariate analysis, positivity of para-aortic nodes (p=0.01 for DFS and p=0.01 for OS) and emboli on completion hysterectomy (p=0.03 for DFS and p=0.006 for OS) were significant. Conclusion: Only patients without para-aortic metastases or limited pelvic involvement and with residual disease and emboli seem to be good candidates for completion surgery.