PT  - JOURNAL ARTICLE
AU  - KATALIN GOMBOS
AU  - RÓBERT HORVÁTH
AU  - ESZTER SZELE
AU  - KRISZTINA JUHÁSZ
AU  - KATALIN GőCZE
AU  - KÁROLY SOMLAI
AU  - GÁBOR PAJKOS
AU  - ISTVÁN EMBER
AU  - LAJOS OLASZ
TI  - miRNA Expression Profiles of Oral Squamous Cell Carcinomas
DP  - 2013 Apr 01
TA  - Anticancer Research
PG  - 1511--1517
VI  - 33
IP  - 4
4099  - http://ar.iiarjournals.org/content/33/4/1511.short
4100  - http://ar.iiarjournals.org/content/33/4/1511.full
SO  - Anticancer Res2013 Apr 01; 33
AB  - Background: Oral squamous cell carcinoma (OSCC) development involves complex machinery of genomic and epigenetic regulations including microRNA (miRNA) expression changes. We aimed to analyze the expression patterns of a set of miRNAs in human TNM stage I and II OSCC samples in an autologous normal mucosa-controlled experimental design. Materials and Methods: Forty samples of OSCC and 40 matched normal tissues were evaluated for miR-21, miR-155, miR-191, miR-146a, miR-221 and miR-222 expression in a LightCycler 480(PCR) system. Results: Our results showed significant overexpression of miR-21, miR-155, miR-191 and miR-221 in paired-sample t-test and the sensitivity/specificity of tests were over 90% in the case of miR-21 and miR-155 on the receiver operating characteristic curve (ROC) analysis. Conclusion: Our results underline the role of miR-21 in OSCC and support the possible causal role of miR-155 and miR-221 in oral carcinogenesis. The overexpression of miR-191 is a novel finding in squamous cell carcinoma.