PT - JOURNAL ARTICLE AU - KOJI KOMORI AU - YUKIHIDE KANEMITSU AU - KENYA KIMURA AU - NORIFUMI HATTORI AU - TSUYOSHI SANO AU - SEIJI ITO AU - TETSUYA ABE AU - YOSHIKI SENDA AU - KAZUNARI MISAWA AU - YUICHI ITO AU - NORIHISA UEMURA AU - YASUHIRO SHIMIZU TI - Tumor Necrosis in Patients with TNM Stage IV Colorectal Cancer without Residual Disease (R0 Status) Is Associated with a Poor Prognosis DP - 2013 Mar 01 TA - Anticancer Research PG - 1099--1105 VI - 33 IP - 3 4099 - http://ar.iiarjournals.org/content/33/3/1099.short 4100 - http://ar.iiarjournals.org/content/33/3/1099.full SO - Anticancer Res2013 Mar 01; 33 AB - Aim: To examine the usefulness of the histopathological finding of tumor necrosis for stratifying TNM stage IV colorectal cancer in R0 status. Patients and Methods: We enrolled 98 patients with stage IV colorectal cancer, without residual disease after resection. The extent of necrosis was assessed using published thresholds, the extent was graded as “absent”, “moderate” (<30% of tumor area), or “severe” (≥30%) in each section. Results: In multivariate analysis, the only significant difference in the disease-free survival rate was related to tumor necrosis (p=0.01) and the significant differences in the overall survival rates were related to the maximum tumor size and the degree of tumor necrosis (p=0.02 and p=0.001, respectively). Conclusion: Tumor necrosis is associated with a poor prognosis in colorectal cancer and may allow the stratification of TNM stage IV patients without residual disease after surgery.