RT Journal Article
SR Electronic
T1 Functional Polymorphism in the <em>CAV1</em> T29107A Gene and Its Association with Prostate Cancer Risk among Japanese Men
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1023
OP 1027
VO 33
IS 3
A1 SATORU SUGIE
A1 HIROMASA TSUKINO
A1 TAKENORI YAMAUCHI
A1 SHOICHIRO MUKAI
A1 MASATO FUJII
A1 NORIHIKO SHIBATA
A1 YOSHIKI KURODA
A1 TOSHIYUKI KAMOTO
YR 2013
UL http://ar.iiarjournals.org/content/33/3/1023.abstract
AB Aim: To evaluate the relationship between the Caveolin-1 (CAV1) T29107A (rs7804372) polymorphism and the risk of prostate cancer among Japanese populations, and the associations between CAV1 polymorphisms and clinicopathological characteristics, including Gleason grade and prostate-specific antigen (PSA) grade. Materials and Methods: We recruited 134 patients with prostate cancer and 86 healthy controls matched for age and smoking status. The CAV1 T29107A polymorphism status was determined by polymerase chain reaction and restriction fragment-length polymorphism analysis. Results: Genotype distributions (p=0.0045) and allelic frequencies (p=0.0018) differed between prostate cancer and control groups in terms of the CAV1 T29107A polymorphism (Pearson's χ2 test). Logistic regression analysis of case and control outcomes showed an odds ratio of 0.35 (95% Condifence interval=0.13-0.91, p=0.033) between the TT and AA polymorphisms, indicating a reduced risk of prostate cancer to be associated with the AA polymorphism. Subset analysis revealed no significant associations between this polymorphism and clinicopathological characteristics of prostate cancer. Conclusion: The results of this study demonstrated a relationship between the CAV1 T29107A variant and risk of prostate cancer. This polymorphism thus, merits further investigation as a potential genomic marker for the early detection of prostate cancer. Our results support the hypothesis that the CAV1 T29107A (rs7804372) polymorphism may influence susceptibility to prostate cancer; however, prostate cancer progression was not associated with this polymorphism in a Japanese population.