RT Journal Article
SR Electronic
T1 Adenocarcinoma Associated with Perianal Fistulas in Crohn's Disease
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 685
OP 689
VO 33
IS 2
A1 HITOSHI OGAWA
A1 SHO HANEDA
A1 CHIKASHI SHIBATA
A1 KOH MIURA
A1 MUNENORI NAGAO
A1 SHINOBU OHNUMA
A1 ATSUSHI KOHYAMA
A1 MICHIAKI UNNO
YR 2013
UL http://ar.iiarjournals.org/content/33/2/685.abstract
AB Aim: The purpose of the present study was to examine the possible relation between anorectal carcinoma and infliximab therapy for Crohn's disease. Patients and Methods: This study reviewed the medical records of patients with perianal Crohn's disease, who have required surgical intervention at the Tohoku University Hospital since May 2002, when infliximab was approved as a remedy for Crohn's disease in Japan. Results: Ninety-two patients underwent surgery due to perianal Crohn's disease between May 2002 and December 2011. Four out of 92 patients were diagnosed as having anorectal carcinoma associated with perianal fistula. All four patients had advanced carcinoma, and received infliximab before the diagnosis of cancer was made. Infliximab was administered due to an exacerbated anal lesion in three patients. Conclusion: Careful inspection and obtaining of a biopsy sample under anesthesia is recommended for patients with Crohn's disease who have long-standing anal fistulas, especially before infliximab administration due to a possible exacerbation of anal symptoms.