TY - JOUR T1 - Intratumoural Interleukin-2 Therapy Can Induce Regression of Non-resectable Mastocytoma in Dogs JF - Anticancer Research JO - Anticancer Res SP - 161 LP - 165 VL - 33 IS - 1 AU - PAUL G.P.M. ZIEKMAN AU - WILLEM DEN OTTER AU - JURGEN F.V. TAN AU - ERIK TESKE AU - JOLLE KIRPENSTEIJN AU - JAN-WILLEM KOTEN AU - JOHN J.L. JACOBS Y1 - 2013/01/01 UR - http://ar.iiarjournals.org/content/33/1/161.abstract N2 - Aim: Mast cell tumours (MCT) are common skin tumours in dogs. If complete surgical removal of the tumours is not possible, then another therapy is needed. In the current study we tested the therapeutic effect of intratumoural injection of interleukin-2 (IL-2). Materials and Methods: Seven dogs had non-resectable cutaneous MCT. The tumours were injected with 4.5×106 IU IL-2. Results: The early clinical effects in the seven dogs with cutaneous MCT were: complete regression (CR) in two dogs; partial regression (PR) in four, and stable disease (SD) in one dog. The final clinical effects were CR in three dogs, PR in two dogs, and PD in two dogs. Conclusion: This pilot study shows that intratumoural IL-2 application can exert an anti-MCT effect. A larger study would be required to precisely establish the magnitude of the therapeutic effect against MCT. A single application of IL-2 in cases of non-resectable MCT has no observable side-effects. ER -