RT Journal Article
SR Electronic
T1 Semi-automated Volumetric Quantification of Tumor Necrosis in Soft Tissue Sarcoma Using Contrast-enhanced MRI
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4951
OP 4961
VO 32
IS 11
A1 WAYNE L. MONSKY
A1 BEDRO JIN
A1 CHRIS MOLLOY
A1 ROBERT J. CANTER
A1 CHIN SHANG LI
A1 TZU C. LIN
A1 DANIEL BORYS
A1 WALTER MACK
A1 ISAAC KIM
A1 MICHAEL H. BUONOCORE
A1 ABHIJIT J. CHAUDHARI
YR 2012
UL http://ar.iiarjournals.org/content/32/11/4951.abstract
AB Background: Response Evaluation Criteria in Solid Tumors (RECIST)-defined measurements are limited when evaluating soft tissue sarcoma (STS) response to therapy. Histopathological assessment of STS response requires a determination of necrosis following resection. A novel semi-automated technique for volumetric measurement of tumor necrosis, using enhanced magnetic resonance imaging (CE-MRI), is described. Patients and Methods: Eighteen patients with STS were treated with neoadjuvant therapy and then resected. CE-MRI, obtained prior to resection, were evaluated by two observers using semi-automated segmentation. Tumor volume and percent necrosis was compared with histology and RECIST measurements. Results: The median percent necrosis, determined histologically and from CE-MRI, was 71.9% and 67.8%, respectively. Accuracy of these semi-automated measurements was confirmed, being statistically similar to those obtained at histopathological assessment of the resected tumor. High Intra-class correlation co-efficients suggest good inter-observer reproducibility. Tumor necrosis did not correlate with the RECIST measurements. Conclusion: Semi-automated determination of tumor volume and necrosis, using CE-MRI, is suggested to be accurate and reproducible.