TY - JOUR T1 - Semi-automated Volumetric Quantification of Tumor Necrosis in Soft Tissue Sarcoma Using Contrast-enhanced MRI JF - Anticancer Research JO - Anticancer Res SP - 4951 LP - 4961 VL - 32 IS - 11 AU - WAYNE L. MONSKY AU - BEDRO JIN AU - CHRIS MOLLOY AU - ROBERT J. CANTER AU - CHIN SHANG LI AU - TZU C. LIN AU - DANIEL BORYS AU - WALTER MACK AU - ISAAC KIM AU - MICHAEL H. BUONOCORE AU - ABHIJIT J. CHAUDHARI Y1 - 2012/11/01 UR - http://ar.iiarjournals.org/content/32/11/4951.abstract N2 - Background: Response Evaluation Criteria in Solid Tumors (RECIST)-defined measurements are limited when evaluating soft tissue sarcoma (STS) response to therapy. Histopathological assessment of STS response requires a determination of necrosis following resection. A novel semi-automated technique for volumetric measurement of tumor necrosis, using enhanced magnetic resonance imaging (CE-MRI), is described. Patients and Methods: Eighteen patients with STS were treated with neoadjuvant therapy and then resected. CE-MRI, obtained prior to resection, were evaluated by two observers using semi-automated segmentation. Tumor volume and percent necrosis was compared with histology and RECIST measurements. Results: The median percent necrosis, determined histologically and from CE-MRI, was 71.9% and 67.8%, respectively. Accuracy of these semi-automated measurements was confirmed, being statistically similar to those obtained at histopathological assessment of the resected tumor. High Intra-class correlation co-efficients suggest good inter-observer reproducibility. Tumor necrosis did not correlate with the RECIST measurements. Conclusion: Semi-automated determination of tumor volume and necrosis, using CE-MRI, is suggested to be accurate and reproducible. ER -