RT Journal Article
SR Electronic
T1 Relationship between Structure and Antiproliferative Activity of Polymethoxyflavones towards HL60 Cells
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5239
OP 5244
VO 32
IS 12
A1 SATORU KAWAII
A1 TOMOYASU IKUINA
A1 TAKESHI HIKIMA
A1 TETSUO TOKIWANO
A1 YUKO YOSHIZAWA
YR 2012
UL http://ar.iiarjournals.org/content/32/12/5239.abstract
AB As part of our continuing investigation of polymethoxyflavone (PMF) derivatives as potential anticancer substances, a series of PMF derivatives was synthesized. The synthesized compounds were evaluated for cytotoxicity against the promyelocytic leukemic HL60 cell line, and structure–activity relationship correlations were investigated along with previously isolated PMFs from the peel of king orange (Citrus nobilis). 7,3’-Dimethoxyflavone demonstrated the most potent activity among the synthetic PMFs. Consideration of correlation between the methoxylation pattern and antiproliferative activity revealed the importance of the 3’-methoxyl group and the higher degree of methoxylation on the A-ring moiety of PMFs.