TY - JOUR T1 - Relationship between Structure and Antiproliferative Activity of Polymethoxyflavones towards HL60 Cells JF - Anticancer Research JO - Anticancer Res SP - 5239 LP - 5244 VL - 32 IS - 12 AU - SATORU KAWAII AU - TOMOYASU IKUINA AU - TAKESHI HIKIMA AU - TETSUO TOKIWANO AU - YUKO YOSHIZAWA Y1 - 2012/12/01 UR - http://ar.iiarjournals.org/content/32/12/5239.abstract N2 - As part of our continuing investigation of polymethoxyflavone (PMF) derivatives as potential anticancer substances, a series of PMF derivatives was synthesized. The synthesized compounds were evaluated for cytotoxicity against the promyelocytic leukemic HL60 cell line, and structure–activity relationship correlations were investigated along with previously isolated PMFs from the peel of king orange (Citrus nobilis). 7,3’-Dimethoxyflavone demonstrated the most potent activity among the synthetic PMFs. Consideration of correlation between the methoxylation pattern and antiproliferative activity revealed the importance of the 3’-methoxyl group and the higher degree of methoxylation on the A-ring moiety of PMFs. ER -