TY - JOUR T1 - Feasibility of <sup>18</sup>F-Fluorodeoxyglucose Positron-emission Tomography for Preoperative Evaluation of Biliary Tract Cancer JF - Anticancer Research JO - Anticancer Res SP - 5105 LP - 5110 VL - 32 IS - 11 AU - ISAMU YAMADA AU - TETSUO AJIKI AU - KIMIHIKO UENO AU - HIDEHIRO SAWA AU - IZURU OTSUBO AU - YUKO YOSHIDA AU - MAKOTO SHINZEKI AU - HIROCHIKA TOYAMA AU - IPPEI MATSUMOTO AU - TAKUMI FUKUMOTO AU - ATSUNORI NAKAO AU - JOJI KOTANI AU - YONSON KU Y1 - 2012/11/01 UR - http://ar.iiarjournals.org/content/32/11/5105.abstract N2 - 18F-Labeled fluorodeoxyglucose positron-emission tomography (FDG-PET), a rapidly evolving functional imaging modality, has recently been shown to be useful in the diagnosis and staging of various malignant tumors due to focal uptake of FDG-labeled glucose in malignant cell populations. However, the role of FDG-PET in the diagnosis and staging of biliary tract cancer is still controversial and has not yet been fully evaluated. The aim of this study was to determine the clinical importance of FDG-PET in the preoperative evaluation of biliary tract cancer and retrospectively clarify the characteristics of false-negative and false-positive cases. We retrospectively analyzed data for 73 consecutive patients diagnosed with cancer of the biliary tract and were admitted to the Department of Hepato-Biliary-Pancreatic Surgery at Kobe University Hospital for treatment, from January 2007 to August 2009. Since the sensitivity, specificity and positive predictive value (PPV) of FDG-PET in the diagnosis of bile duct carcinoma are usually relatively high, FDG-PET is considered to be a useful tool in diagnosing biliary tract cancer. FDG-PET also seems to be useful in clinical decision-making, regarding treatment strategy, including surgery. Our results showed that FDG-PET is highly sensitive in delineating the primary focus of biliary cancer and is a useful tool in preoperative examination. A disadvantage of FDG-PET is its inability to indicate small metastases and false-positive findings of inflamed gallbladder and bile duct lesions. ER -