RT Journal Article SR Electronic T1 A Study of Serum Biomarkers Associated with Relapse of Cervical Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4913 OP 4922 VO 32 IS 11 A1 LOUISE BOHR MORDHORST A1 BENGT SORBE A1 CECILIA AHLIN YR 2012 UL http://ar.iiarjournals.org/content/32/11/4913.abstract AB Background/Aim: To discover candidate protein biomarkers in the serum of patients with cervical cancer that differentiate between patients with relapse from those who are tumor-free after primary treatment with (platinum-based chemo-) radiation. Patients and Methods: Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) with cation exchange (CM10) and hydrophobic/reverse-phase (H50) was used to examine 44 serum samples from patients with advanced cervical cancer, primarily treated with (platinum-based chemo-) radiation. Results: Ten candidate biomarkers were identified in the serum of 34 patients. Six candidate markers were elevated in patients with no relapse and four were elevated in patients with relapse [p=0.007-0.11; area under the curve (AUC)=0.70-0.75]. Masses of candidate biomarkers ranged from 2,022 to 116,165 Da. Conclusion: Patients with relapse from primary advanced cervical cancer exhibit different serum protein expression profiles from those with no relapse.