@article {MORDHORST4913, author = {LOUISE BOHR MORDHORST and BENGT SORBE and CECILIA AHLIN}, title = {A Study of Serum Biomarkers Associated with Relapse of Cervical Cancer}, volume = {32}, number = {11}, pages = {4913--4922}, year = {2012}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: To discover candidate protein biomarkers in the serum of patients with cervical cancer that differentiate between patients with relapse from those who are tumor-free after primary treatment with (platinum-based chemo-) radiation. Patients and Methods: Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) with cation exchange (CM10) and hydrophobic/reverse-phase (H50) was used to examine 44 serum samples from patients with advanced cervical cancer, primarily treated with (platinum-based chemo-) radiation. Results: Ten candidate biomarkers were identified in the serum of 34 patients. Six candidate markers were elevated in patients with no relapse and four were elevated in patients with relapse [p=0.007-0.11; area under the curve (AUC)=0.70-0.75]. Masses of candidate biomarkers ranged from 2,022 to 116,165 Da. Conclusion: Patients with relapse from primary advanced cervical cancer exhibit different serum protein expression profiles from those with no relapse.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/32/11/4913}, eprint = {https://ar.iiarjournals.org/content/32/11/4913.full.pdf}, journal = {Anticancer Research} }