RT Journal Article
SR Electronic
T1 Comparison of Two Different Conditioning Regimens Before Autologous Transplantation for Children with High-Risk Neuroblastoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5527
OP 5533
VO 32
IS 12
A1 MARIA ANTONIETTA DE IORIS
A1 BENEDETTA CONTOLI
A1 ALESSANDRO JENKNER
A1 MARIA DEBORA DE PASQUALE
A1 ANNALISA SERRA
A1 LUIGI DE SIO
A1 ROSANNA PESSOLANO
A1 MARIA CARMEN GARGANESE
A1 ALESSANDRO CROCOLI
A1 TERESA CORNELI
A1 RENATA BOLDRINI
A1 AURORA CASTELLANO
YR 2012
UL http://ar.iiarjournals.org/content/32/12/5527.abstract
AB Background: Although high-dose chemotherapy (HDC) represents the standard of treatment for high-risk neuroblastoma (NBL), the most effective conditioning regimen still remains to be identified. Patients and Methods: Forty-one high-risk NBL entered into local protocol based on induction chemotherapy, surgery and HDC with either etoposide/thiotepa/cyclophophamide (ETC) or i.v. busulfan and L-PAM (Bu/L-PAM). Results: Thirty-seven patients underwent HDC; 29 with ETC and 8 with Bu/L-PAM. No toxic deaths were recorded. The 5-year progression-free survival (PFS) of patients given ETC was 21% (95% confidence interval CI (9-36%), while PFS for patients given Bu/L-PAM was 88% (95% CI=39-98%) (p<0.05). In multivariate analysis, treatment with the ETC regimen predicted progression/recurrence with a hazard ratio (HR) of 16.8 (p<0.05), as well as MYCN amplification which had an HR of 4.4 (p<0.05). Conclusion: Although the number of studied cases is limited, our data suggest that in high-risk NBL the combination of Bu/L-PAM is superior to the ETC regimen.