TY - JOUR T1 - Comparison of Two Different Conditioning Regimens Before Autologous Transplantation for Children with High-Risk Neuroblastoma JF - Anticancer Research JO - Anticancer Res SP - 5527 LP - 5533 VL - 32 IS - 12 AU - MARIA ANTONIETTA DE IORIS AU - BENEDETTA CONTOLI AU - ALESSANDRO JENKNER AU - MARIA DEBORA DE PASQUALE AU - ANNALISA SERRA AU - LUIGI DE SIO AU - ROSANNA PESSOLANO AU - MARIA CARMEN GARGANESE AU - ALESSANDRO CROCOLI AU - TERESA CORNELI AU - RENATA BOLDRINI AU - AURORA CASTELLANO Y1 - 2012/12/01 UR - http://ar.iiarjournals.org/content/32/12/5527.abstract N2 - Background: Although high-dose chemotherapy (HDC) represents the standard of treatment for high-risk neuroblastoma (NBL), the most effective conditioning regimen still remains to be identified. Patients and Methods: Forty-one high-risk NBL entered into local protocol based on induction chemotherapy, surgery and HDC with either etoposide/thiotepa/cyclophophamide (ETC) or i.v. busulfan and L-PAM (Bu/L-PAM). Results: Thirty-seven patients underwent HDC; 29 with ETC and 8 with Bu/L-PAM. No toxic deaths were recorded. The 5-year progression-free survival (PFS) of patients given ETC was 21% (95% confidence interval CI (9-36%), while PFS for patients given Bu/L-PAM was 88% (95% CI=39-98%) (p<0.05). In multivariate analysis, treatment with the ETC regimen predicted progression/recurrence with a hazard ratio (HR) of 16.8 (p<0.05), as well as MYCN amplification which had an HR of 4.4 (p<0.05). Conclusion: Although the number of studied cases is limited, our data suggest that in high-risk NBL the combination of Bu/L-PAM is superior to the ETC regimen. ER -