@article {DE IORIS5527, author = {MARIA ANTONIETTA DE IORIS and BENEDETTA CONTOLI and ALESSANDRO JENKNER and MARIA DEBORA DE PASQUALE and ANNALISA SERRA and LUIGI DE SIO and ROSANNA PESSOLANO and MARIA CARMEN GARGANESE and ALESSANDRO CROCOLI and TERESA CORNELI and RENATA BOLDRINI and AURORA CASTELLANO}, title = {Comparison of Two Different Conditioning Regimens Before Autologous Transplantation for Children with High-Risk Neuroblastoma}, volume = {32}, number = {12}, pages = {5527--5533}, year = {2012}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Although high-dose chemotherapy (HDC) represents the standard of treatment for high-risk neuroblastoma (NBL), the most effective conditioning regimen still remains to be identified. Patients and Methods: Forty-one high-risk NBL entered into local protocol based on induction chemotherapy, surgery and HDC with either etoposide/thiotepa/cyclophophamide (ETC) or i.v. busulfan and L-PAM (Bu/L-PAM). Results: Thirty-seven patients underwent HDC; 29 with ETC and 8 with Bu/L-PAM. No toxic deaths were recorded. The 5-year progression-free survival (PFS) of patients given ETC was 21\% (95\% confidence interval CI (9-36\%), while PFS for patients given Bu/L-PAM was 88\% (95\% CI=39-98\%) (p\<0.05). In multivariate analysis, treatment with the ETC regimen predicted progression/recurrence with a hazard ratio (HR) of 16.8 (p\<0.05), as well as MYCN amplification which had an HR of 4.4 (p\<0.05). Conclusion: Although the number of studied cases is limited, our data suggest that in high-risk NBL the combination of Bu/L-PAM is superior to the ETC regimen.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/32/12/5527}, eprint = {https://ar.iiarjournals.org/content/32/12/5527.full.pdf}, journal = {Anticancer Research} }