PT  - JOURNAL ARTICLE
AU  - DANIEL G. PONS
AU  - JORGE SASTRE-SERRA
AU  - MERCEDES NADAL-SERRANO
AU  - AINA OLIVER
AU  - MAGDALENA GARCÍA-BONAFÉ
AU  - ISABEL BOVER
AU  - PILAR ROCA
AU  - JORDI OLIVER
TI  - Initial Activation Status of the Antioxidant Response Determines Sensitivity to Carboplatin/Paclitaxel Treatment of Ovarian Cancer
DP  - 2012 Nov 01
TA  - Anticancer Research
PG  - 4723--4728
VI  - 32
IP  - 11
4099  - http://ar.iiarjournals.org/content/32/11/4723.short
4100  - http://ar.iiarjournals.org/content/32/11/4723.full
SO  - Anticancer Res2012 Nov 01; 32
AB  - Background/Aim: Ovarian carcinoma is the main cause of gynecological cancer related deaths. The aim of this study was to determine the activation status of the antioxidant response in samples of ovarian serous carcinoma from paraffin-embedded biopsies and compare them with the response of patients to carboplatin-paclitaxel treatment. Materials and Methods: Estrogen receptor alpha (ERα), antioxidant enzymes, and uncoupling protein (UCP) levels were analyzed by western blotting and the presence of estrogen receptor beta (ERβ) was investigated by immunohistochemistry (IHC). Results: Lower levels of ERα, antioxidant enzymes and UCPs were found in patients resistant to treatment in comparison to the carboplatin/paclitaxel-sensitive ones; IHC revealed a greater presence of ERβ in sensitive patients. Conclusion: These results indicate that patients resistant to treatment have a lower level of antioxidant response activation compared to sensitive patients, fact which may be related to the efficacy of this treatment.