TY - JOUR T1 - Early Relapse Is Associated with High Serum Soluble Interleukin-2 Receptor after the Sixth Cycle of R-CHOP Chemotherapy in Patients with Advanced Diffuse Large B-Cell Lymphoma JF - Anticancer Research JO - Anticancer Res SP - 5051 LP - 5057 VL - 32 IS - 11 AU - TAKAHIRO YAMAUCHI AU - YASUFUMI MATSUDA AU - MIHOKO TAKAI AU - TOSHIKI TASAKI AU - KATSUNORI TAI AU - NAOKO HOSONO AU - EIJU NEGORO AU - SATOSHI IKEGAYA AU - KAZUTAKA TAKAGI AU - SHINJI KISHI AU - AKIRA YOSHIDA AU - YOSHIMASA URASAKI AU - HIROMICHI IWASAKI AU - TAKANORI UEDA Y1 - 2012/11/01 UR - http://ar.iiarjournals.org/content/32/11/5051.abstract N2 - The clinical significance of serum soluble interleukin-2 receptor (sIL2R) levels was retrospectively assessed in patients with advanced diffuse large B-cell lymphoma (DLBCL). Twenty-one patients, who were newly-diagnosed with advanced DLBCL (stage III and IV) between 2006 and 2009, were evaluated. The median follow-up period was 37 months. All patients received 6-8 cycles of chemotherapy with rituximab in combination with doxorubicin, cyclophosphamide, vincristine, and prednisolone (CHOP)–like regimens and attained complete remission. Although all patients reached complete remission, six patients experienced disease relapse within 1 year after treatment completion. The overall survival was significantly poorer in patients with relapse than in patients with durable remission. The sIL2R levels after the sixth cycle of treatment were significantly higher in the relapse group than in the non-relapse group. Thus, the present study suggests sIL2R levels to be a valuable predictor for the prognosis of patients with advanced DLBCL. ER -