%0 Journal Article %A MARIA PIPERIS %A XENI PROVATOPOULOU %A ALEXANDROS SAGKRIOTIS %A ELENI KALOGERA %A EMMANOUIL AMPATZOGLOU %A GEORGE C. ZOGRAFOS %A ELENI ATHANASIOU %A ANTONIA GOUNARIS %T Effect of Breast Cancer Adjuvant Therapies on Potential Biomarkers of Pulmonary Inflammation %D 2012 %J Anticancer Research %P 4993-5002 %V 32 %N 11 %X Background: The aim of this study was to investigate the effect of breast cancer adjuvant therapies on the levels of circulating surfactant protein-D (SP-D), C-Reactive protein (CRP) and soluble receptor for advanced glycation end-products (sRAGE), as potential biomarkers of subclinical pulmonary inflammation. Materials and Methods: The soluble molecules were serially determined in 38 patients, prior to the initiation of radiation therapy (RT) and during adjuvant treatment, using immunoassays. Results: Significantly higher levels of all three biomarkers were observed in patients prior to the initiation of RT compared to healthy controls (CRP: p<0.001, SP-D: p<0.05, sRAGE: p<0.05). SP-D levels exhibited a gradual increase after RT and during follow-up (p<0.005). Patients treated with a combination of RT and hormonal therapy presented a significant, but less pronounced, increase in SP-D and a significant decrease in CRP compared to those who did not receive hormonal therapy (p=0.0428 and p=0.0116, respectively). Patients treated with a combination of RT and trastuzumab presented a significant increase in SP-D levels (p=0.0310). Conclusion: The average rate of change in the levels of circulating SP-D and CRP during postoperative irradiation and adjuvant hormonal therapy suggests that the combined therapeutic regiment may potentially exert important anti-inflammatory effects on the lung. On the contrary, combined administration of RT and trastuzumab is likely to induce or provoke pulmonary inflammation. %U https://ar.iiarjournals.org/content/anticanres/32/11/4993.full.pdf