RT Journal Article SR Electronic T1 Effectiveness of a 12-month Exercise Program on Physical Performance and Quality of Life of Breast Cancer Survivors JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 3875 OP 3884 VO 32 IS 9 A1 TIINA SAARTO A1 HEIDI MARIKA PENTTINEN A1 HARRI SIEVÄNEN A1 PIRKKO-LIISA KELLOKUMPU-LEHTINEN A1 LIISA HAKAMIES-BLOMQVIST A1 RIKU NIKANDER A1 RIIKKA HUOVINEN A1 RIITTA LUOTO A1 HANNU KAUTIAINEN A1 SALME JÄRVENPÄÄ A1 IRJA IDMAN A1 MERI UTRIAINEN A1 LEENA VEHMANEN A1 ANNA-STINA JÄÄSKELÄINEN A1 ANNELI ELME A1 JOHANNA RUOHOLA A1 TIINA PALVA A1 HARRI VERTIO A1 MATTI RAUTALAHTI A1 MIKAEL FOGELHOLM A1 CARL BLOMQVIST A1 MINNA-LIISA LUOMA YR 2012 UL http://ar.iiarjournals.org/content/32/9/3875.abstract AB Aim: The study aimed at determining whether physical exercise training improves the quality of life (QoL) and physical fitness of breast cancer survivors. Patients and Methods: A total of 573 breast cancer survivors were randomized into an exercise or a control group, 12-months after adjuvant treatments. EORTC QLQ-C30 and BR-23 questionnaires were used for evaluation of QoL, FACIT-F for fatigue and the Finnish modified version of Beck's 13-item depression scale (RBDI) for depression. Physical fitness was assessed by a 2-km walking test, and a figure-8 running test and physical activity (PA) by metabolic equivalent (MET) hours per week (MET-h/wk). Results: Figure-8 running time improved significantly among the patients of the intervention group compared with the controls (p<0.001). No significant between-group differences were observed in 2-km walking time, in PA, EORTC-QLQ-C30, BR-23, FACIT-F or BDI. However, there was a linear relationship between increased PA and improved QoL (p=0.006), irrespective of the intervention. Conclusion: Increase in physical activity was associated with improved QoL, but no effect of the exercise intervention was observed.