TY - JOUR T1 - Impact of Immunohistochemical Analysis of Sentinel Lymph Node Biopsy on Breast Cancer Management JF - Anticancer Research JO - Anticancer Res SP - 3403 LP - 3409 VL - 32 IS - 8 AU - ELISABETH CHÉREAU AU - CORINNE BEZU AU - JOSEPH GLIGOROV AU - RITA SAKR AU - MARTINE ANTOINE AU - EMILE DARAÏ AU - SERGE UZAN AU - ROMAN ROUZIER Y1 - 2012/08/01 UR - http://ar.iiarjournals.org/content/32/8/3403.abstract N2 - Background: Little evidence of the impact of immunohistochemical analysis (IHC) on the indications for adjuvant therapies is available. This study determined the modification rate of adjuvant chemotherapy and lymph node area radiotherapy using IHC and its impact on survival. Patients and Methods: Between 2001 and 2005, 416 patients underwent surgery for invasive breast cancer with sentinel lymph node (SLN) biopsy. Results: A total of 112 patients had positive SLNs: 12.5% isolated tumor cells, 35.7% micrometastasis and 51.8% macrometastasis. Only 4% of patients (14 out of 342 patients) had modified indications for chemotherapy and 7% of patients (25 out of 342) for lymph node area radiotherapy due to IHC findings. Conclusion: IHC analysis led to modifications in adjuvant chemotherapy and lymph node area radiotherapy in 4% and 7% of patients, respectively. The prognosis of patients with nodal metastasis discovered by ultrastaging was similar to that for conventional Haematoxylin-Eosin-Safran (HES) staining. Our data support the use of SLN ultrastaging. ER -