PT - JOURNAL ARTICLE AU - MASAHARU HATA AU - IZUMI KOIKE AU - HIDEFUMI WADA AU - ETSUKO MIYAGI AU - KAZUMASA ODAGIRI AU - YUMIKO MINAGAWA AU - TAKEO KASUYA AU - HISASHI KAIZU AU - TOMIO INOUE TI - Definitive Radiation Therapy for Extramammary Paget's Disease DP - 2012 Aug 01 TA - Anticancer Research PG - 3315--3320 VI - 32 IP - 8 4099 - http://ar.iiarjournals.org/content/32/8/3315.short 4100 - http://ar.iiarjournals.org/content/32/8/3315.full SO - Anticancer Res2012 Aug 01; 32 AB - Background: Extramammary Paget's disease (EMPD) is frequently inoperable because of old age and/or coexisting disease. We therefore reviewed the efficacy and toxicity of radiation therapy for EMPD. Patients and Methods: Fourteen patients with EMPD underwent definitive radiation therapy. Three patients had regional lymph node metastases before radiation therapy, but none had distant metastasis. Total doses of 52-80.2 Gy (median=60.6 Gy) were delivered to tumor sites in 26-43 fractions (median=33 fractions). Results: Four patients had developed recurrence at a median follow-up period of 47 months. The 5-year local control and disease-free rates were 71% and 63%, respectively. Two patients died of old age and renal failure at 6 and 51 months, respectively, after irradiation. The 5-year disease-free, cause-specific and overall survival rates were 46%, 100% and 79%, respectively. No therapy-related toxicities of grade 3 or greater were observed. Conclusion: Radiation therapy is effective and safe, and appears to offer a curative treatment option for patients with EMPD.