RT Journal Article
SR Electronic
T1 Circulating Vascular Endothelial Growth Factor in Childhood Solid Tumors: Plasma and Serum Measurements
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3565
OP 3569
VO 32
IS 8
A1 AMALIA SCHIAVETTI
A1 ANNAPAOLA INGROSSO
A1 ANNA ANTENUCCI
A1 TATIANA FEDERICI
A1 GIACOMINA MEGARO
A1 LAURA DE LUCA
A1 LAURA CONTI
YR 2012
UL http://ar.iiarjournals.org/content/32/8/3565.abstract
AB Background: Serum and plasma vascular endothelial growth factor (VEGF) were measured in children with a solid tumor to investigate which provides better prognostic information. Patients and Methods: Seventeen patients under treatment were divided into two groups: without (n 8) and with (n 9) detectable disease at radiological assessment (groups I and II). The control group consisted of 26 healthy children. VEGF was tested by enzyme-linked ELISA kit. Results: Serum VEGF concentrations in group II were statistically higher than those in group I (p<0.05) and those in controls (p=0.001), whereas the difference between group I and controls was not statistically significant (p=0.067). Plasma VEGF concentrations in group II were also statistically higher than those in group I (p<0.01) and those in controls (p=0.0001); the difference between group I and controls was also statistically significant (p=0.004). Conclusion: Plasma would be the more useful specimen for measurement of circulating VEGF in cancer childhood.