RT Journal Article
SR Electronic
T1 hGH and GHR Expression in Large Cell Neuroendocrine Carcinoma of the Colon and Rectum
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3377
OP 3381
VO 32
IS 8
A1 ZORAN JUKIĆ
A1 RINË LIMANI
A1 LUMTURIJE GASHI LUCI
A1 VIVIAN NIKIĆ
A1 AUGUST MIJIĆ
A1 DAVOR TOMAS
A1 BOŽO KRUŠLIN
YR 2012
UL http://ar.iiarjournals.org/content/32/8/3377.abstract
AB Large cell neuroendocrine carcinoma (LCNEC) is an aggressive neoplasm with a low frequency of occurrence in the digestive tract. We present a series of eight patients diagnosed with LCNEC of the colon and rectum. Grossly, tumors were presented as endophytic/ulcerative, annular and polypoid masses, with a gray-white color and necrosis in most cases. Histologically, they were high-grade tumors composed of large cells of organoid, nesting, trabecular, rosette-like and palisading patterns, with a high mitotic rate. Tumors were immunoreactive for neuroendocrine markers, including chromogranin A (2/8), synaptophysin (7/8), and neuron-specific enolase (8/8). Moreover, we analyzed the expression of growth hormone (hGH) and growth hormone receptor (GHR) in colorectal LCNECs and six tumors were immunoreactive for hGH, while five tumors were immunoreactive for GHR. To our knowledge hGH and GHR expression has not been previously analyzed in colorectal LCNEC. Their overexpression suggests a role of hGH and GHR in the development of colorectal LCNEC.