TY - JOUR T1 - Yes-associated Protein Is Not an Independent Prognostic Marker in Breast Cancer JF - Anticancer Research JO - Anticancer Res SP - 3321 LP - 3325 VL - 32 IS - 8 AU - SHYR-MING SHEEN-CHEN AU - CHUN-YING HUANG AU - CHING-HUA TSAI AU - YUEH-WEI LIU AU - SHIH-CHUNG WU AU - CHAO-CHENG HUANG AU - HOCK-LIEW ENG AU - YI-CHIA CHAN AU - SHEUNG-FAT KO AU - REI-PING TANG Y1 - 2012/08/01 UR - http://ar.iiarjournals.org/content/32/8/3321.abstract N2 - Background: The development of tissue microarray (TMA) technology has provided the opportunity to perform analyses of tissue samples on a large scale in an uniform fashion. This study was designed with the use of TMA to explore the Yes-associated protein (YAP) status in breast cancer. Patients and Methods: YAP expression in tumor and tumor-free samples from 94 patients with primary breast cancer was analyzed by TMA. The clinicopathological data for age, estrogen receptor status, histological grading and TNM staging were also collected. Results: There were 29 patients (30.8%) with 1+ expression, in YAP, 59 patients (62.8%) with 2+ expression and 6 (6.4%) with 3+ expression. There was no significant relationship between YAP expression and the other clinicopathological variables. By multivariate analysis, YAP expression failed to produce any significant relationship with the overall survival rate. Conclusion: YAP expression is not an independent prognostic factor in patients with breast cancer. ER -