RT Journal Article
SR Electronic
T1 Yes-associated Protein Is Not an Independent Prognostic Marker in Breast Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3321
OP 3325
VO 32
IS 8
A1 SHYR-MING SHEEN-CHEN
A1 CHUN-YING HUANG
A1 CHING-HUA TSAI
A1 YUEH-WEI LIU
A1 SHIH-CHUNG WU
A1 CHAO-CHENG HUANG
A1 HOCK-LIEW ENG
A1 YI-CHIA CHAN
A1 SHEUNG-FAT KO
A1 REI-PING TANG
YR 2012
UL http://ar.iiarjournals.org/content/32/8/3321.abstract
AB Background: The development of tissue microarray (TMA) technology has provided the opportunity to perform analyses of tissue samples on a large scale in an uniform fashion. This study was designed with the use of TMA to explore the Yes-associated protein (YAP) status in breast cancer. Patients and Methods: YAP expression in tumor and tumor-free samples from 94 patients with primary breast cancer was analyzed by TMA. The clinicopathological data for age, estrogen receptor status, histological grading and TNM staging were also collected. Results: There were 29 patients (30.8%) with 1+ expression, in YAP, 59 patients (62.8%) with 2+ expression and 6 (6.4%) with 3+ expression. There was no significant relationship between YAP expression and the other clinicopathological variables. By multivariate analysis, YAP expression failed to produce any significant relationship with the overall survival rate. Conclusion: YAP expression is not an independent prognostic factor in patients with breast cancer.