RT Journal Article
SR Electronic
T1 Down-regulation of 8-Hydroxydeoxyguanosine and Peroxiredoxin II in the Pathogenesis of Endometriosis-associated Ovarian Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3037
OP 3044
VO 32
IS 8
A1 HENRI SOVA
A1 JUHA KANGAS
A1 ULLA PUISTOLA
A1 MARKKU SANTALA
A1 ANNIKKI LIAKKA
A1 PEETER KARIHTALA
YR 2012
UL http://ar.iiarjournals.org/content/32/8/3037.abstract
AB Aim: To evaluate the roles of oxidative stress marker 8-hydroxydeoxyguanosine (8-OHdG) and peroxiredoxin (PRX) antioxidants in the development of endometriosis and endometriosis-associated ovarian cancer (EAC). Materials and Methods: Tissue expressions of 8-OHdG, PRX II and PRX IV were determined immunohistochemically in tissue from 22 women with benign endometriosis (BE) and 33 women with EAC, among whom endometriosis and cancer tissues were analyzed separately. Results: When all three groups were compared simultaneously, EAC tumor cells had significantly weaker nuclear 8-OHdG and PRX II expression (p<0.05 and p<0.01, respectively) and significantly weaker cytoplasmic 8-OHdG expression (p<0.01) than EAC endometriosis and BE epithelial cells. This same trend was also observed when groups were compared pair-wise. Conclusion: Nuclear PRX II and 8-OHdG were down-regulated in EAC tumorous tissue compared with BE and EAC endometriotic tissue, suggesting a role of oxidative stress in the pathogenesis of EAC.