%0 Journal Article %A NOBUYUKI KIKUNO %A TAKAFUMI KENNOKI %A HIRONORI FUKUDA %A YUICHI MATSUMOTO %A KUNIKO TSUNOYAMA %A SHINICHI BAN %A HIDEAKI SATOH %A OSAMU RYOJI %T Brain Metastasis in a Patient with a Sarcomatoid Variant RCC with Well-controlled Extracerebral Metastases by Temsirolimus %D 2012 %J Anticancer Research %P 3443-3447 %V 32 %N 8 %X Background: The sarcomatoid variant of metastatic renal cell carcinoma (RCC) has often an aggressive course and a poor prognosis, particularly when accompanied with brain metastasis. Case Report: We describe the case of a patient with sarcomatoid variant RCC in whom brain metastasis was observed as a new lesion during treatment with temsirolimus, despite other extracerebral metastatic lesions being well-controlled and progression-free. Results: This discrepancy between the effectiveness of temsirolimus for extracerebral metastases and the simultaneous progression of brain metastases of RCC raises a concern that while vascular endothelial growth factor (VEGF)-targeted therapy may have clinical efficacy, it may also carry a risk for new brain metastases due to weakening of the structure of the blood brain barrier. Conclusion: This case indicates that computed tomography monitoring of the brain should be regularly performed during VEGF-targeted therapy in patients with sarcomatoid variant RCC, even if brain metastases are absent and extracerebral metastatic lesions are well controlled. %U https://ar.iiarjournals.org/content/anticanres/32/8/3443.full.pdf