RT Journal Article
SR Electronic
T1 Colon Neoplastic Cells Do Not Originate from Bone Marrow-derived Cells after Sex-mismatched Bone Marrow Transplantation
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4097
OP 4103
VO 32
IS 9
A1 SAKAI, GEN
A1 YAJIMA, TOMOHARU
A1 TAKAISHI, HIROMASA
A1 MORI, TAKEHIKO
A1 HIGUCHI, HAJIME
A1 NAKAMURA, SHOKO
A1 FUNAKOSHI, SHINSUKE
A1 ADACHI, MASAYUKI
A1 IZUMIYA, MOTOKO
A1 AKAGI, HIDEKO
A1 HAMAMOTO, YASUO
A1 KANAI, TAKANORI
A1 MUKAI, MAKIO
A1 OKAMOTO, SHINICHIRO
A1 HIBI, TOSHIFUMI
YR 2012
UL http://ar.iiarjournals.org/content/32/9/4097.abstract
AB Background: Although previous studies indicate that gastrointestinal (GI) cancer may originate from cells recruited from bone marrow (BM) in mice, whether similar phenomena occur in humans is controversial. In the current study, we evaluated two female patients who developed colonic adenocarcinoma more than 10 years after gender-mismatched BM transplantation, and followingly underwent successful endoscopic mucosal resection. Materials and Methods: Fluorescent in situ hybridization (FISH) analysis was used to determine whether the tumours contained donor-derived BM cells. Results: Approximately 1.2% of the tumour cells contained Y-chromosome-positive signals, and a comparable percentage of normal colonic epithelial cells close to the tumour also contained Y-chromosome-positive signals. Conclusion: These results do not support the concept that GI cancer can originate from BM-derived cells.