PT  - JOURNAL ARTICLE
AU  - SAKAI, GEN
AU  - YAJIMA, TOMOHARU
AU  - TAKAISHI, HIROMASA
AU  - MORI, TAKEHIKO
AU  - HIGUCHI, HAJIME
AU  - NAKAMURA, SHOKO
AU  - FUNAKOSHI, SHINSUKE
AU  - ADACHI, MASAYUKI
AU  - IZUMIYA, MOTOKO
AU  - AKAGI, HIDEKO
AU  - HAMAMOTO, YASUO
AU  - KANAI, TAKANORI
AU  - MUKAI, MAKIO
AU  - OKAMOTO, SHINICHIRO
AU  - HIBI, TOSHIFUMI
TI  - Colon Neoplastic Cells Do Not Originate from Bone Marrow-derived Cells after Sex-mismatched Bone Marrow Transplantation
DP  - 2012 Sep 01
TA  - Anticancer Research
PG  - 4097--4103
VI  - 32
IP  - 9
4099  - http://ar.iiarjournals.org/content/32/9/4097.short
4100  - http://ar.iiarjournals.org/content/32/9/4097.full
SO  - Anticancer Res2012 Sep 01; 32
AB  - Background: Although previous studies indicate that gastrointestinal (GI) cancer may originate from cells recruited from bone marrow (BM) in mice, whether similar phenomena occur in humans is controversial. In the current study, we evaluated two female patients who developed colonic adenocarcinoma more than 10 years after gender-mismatched BM transplantation, and followingly underwent successful endoscopic mucosal resection. Materials and Methods: Fluorescent in situ hybridization (FISH) analysis was used to determine whether the tumours contained donor-derived BM cells. Results: Approximately 1.2% of the tumour cells contained Y-chromosome-positive signals, and a comparable percentage of normal colonic epithelial cells close to the tumour also contained Y-chromosome-positive signals. Conclusion: These results do not support the concept that GI cancer can originate from BM-derived cells.