RT Journal Article SR Electronic T1 Delta-tocotrienol Augments Cisplatin-induced Suppression of Non-small Cell Lung Cancer Cells via Inhibition of the Notch-1 Pathway JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2647 OP 2655 VO 32 IS 7 A1 XIANGMING JI A1 ZHIWEI WANG A1 FAZLUL H. SARKAR A1 SMITI V. GUPTA YR 2012 UL http://ar.iiarjournals.org/content/32/7/2647.abstract AB Non-small cell lung cancer (NSCLC), accounting for 80% of lung cancers, is the leading cause of all cancer deaths. Previously, we demonstrated that delta-tocotrienol inhibits NSCLC cell proliferation, invasion and induces apoptosis by down-regulation of the Notch-1 signaling pathway. The objective of this study was to investigate whether delta-tocotrienol, could enhance the anticancer effects of cisplatin. Treatment with a combination of delta-tocotrienol and cisplatin resulted in a dose-dependent, significant inhibition of cell growth, migration, invasiveness, and induction of apoptosis in NSCLC cells, as compared to the single agents. This was associated with a decrease in NF-κB DNA binding activity, decrease in Notch-1, Hes-1, Bcl-2 and increase in cleaved Caspase-3 and PARP expressions. These results suggest that down-regulation of Notch-1, via inhibition of NF-κB signaling pathways by delta-tocotrienol and cisplatin, in combination, could provide a potential novel approach for tumor arrest in NSCLC, while lowering the effective dose of cisplatin.