@article {TOMITA3535, author = {MASAKI TOMITA and TETSUYA SHIMIZU and TAKANORI AYABE and TOSHIO ONITSUKA}, title = {Elevated Preoperative Inflammatory Markers Based on Neutrophil-to-Lymphocyte Ratio and C-Reactive Protein Predict Poor Survival in Resected Non-small Cell Lung Cancer}, volume = {32}, number = {8}, pages = {3535--3538}, year = {2012}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Previous studies showed the prognostic impact of inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP), in resected non-small cell lung cancer (NSCLC). However, there are no studies that examined both of these markers simultaneously. Patients and Methods: Three hundred and one consecutive cases of resected NSCLC with a follow-up period of more than 5 years were reviewed retrospectively. Results: A significant association was only observed between NLR and patients{\textquoteright} survival (p\<0.0001). High CRP also led to a higher 5-year survival rate than low CRP (38.71\% vs. 70.71\%, p\<0.0001). We evaluated the prognostic significance of the use of NLR and CRP combined. The 5-year survival of patients with both low NLR and low CRP was 74.18\%. On the other hand, that of patients with both of these at a low level was significantly poor (20.00\%, p\<0.0001). Univariate and multivariate analyses of the clinicopathological factors affecting survival revealed that the combined use of preoperative NLR and CRP was an independent prognostic determinant. Conclusion: The combined use of preoperative NLR and CRP might be useful to predict the prognosis of patients with NSCLC.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/32/8/3535}, eprint = {https://ar.iiarjournals.org/content/32/8/3535.full.pdf}, journal = {Anticancer Research} }