PT - JOURNAL ARTICLE AU - YOSHINORI NIO AU - KAZUHIKO TSUBOI AU - MIKAKO TAMAOKI AU - MASASHI TAMAOKI AU - RIRUKE MARUYAMA TI - Lymphoepithelioma-like Carcinoma of the Breast: A Case Report with a Special Analysis of an Association with Human Papilloma Virus DP - 2012 Apr 01 TA - Anticancer Research PG - 1435--1441 VI - 32 IP - 4 4099 - http://ar.iiarjournals.org/content/32/4/1435.short 4100 - http://ar.iiarjournals.org/content/32/4/1435.full SO - Anticancer Res2012 Apr 01; 32 AB - Lymphoepithelioma-like carcinoma (LELC) of the breast is a very rare tumor, and fewer than 20 cases have been reported. A recent report suggested the implication of human papilloma virus (HPV) in the pathogenesis of breast LELC. We report a case of LELC of the breast with a review of its relevance to an association with HPV. A 45-year-old female patient presented with a solid mass in the outer-upper part of her left breast, which was diagnosed as malignant (ductal carcinoma) by fine-needle aspiration cytology. The patient underwent a quadrantectomy of the breast and axillary sentinel node biopsy. Pathological examination revealed cohesive sheets or nests of malignant epithelial cells, with unclear circumscription in a background of diffuse lymphoid infiltration; the postsurgical clinical stage was pT1pN0M0, stage 1. Immunohistochemistry demonstrated that the tumor was triple negative and basal-like breast cancer. In the present case in situ hybridization demonstrated positive HPV signals in a few tumor cells; however, polymerase chain reaction study failed to detect HPV in tumor cells. Conclusion: To the best of our knowledge, this is the second report on HPV infection associated with breast LELC.