RT Journal Article
SR Electronic
T1 The Role of Canonical WNT Signaling Pathway in Oral Carcinogenesis: A Comprehensive Review
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 873
OP 878
VO 32
IS 3
A1 JULIANA NOGUTI
A1 CAROLINA FOOT GOMES DE MOURA
A1 THAIS AYAKO HOSSAKA
A1 MARCELLO FRANCO
A1 CELINA TIJUKO FUJIYAMA OSHIMA
A1 ROGERIO APARECIDO DEDIVITIS
A1 DANIEL ARAKI RIBEIRO
YR 2012
UL http://ar.iiarjournals.org/content/32/3/873.abstract
AB Oral cancer is a common neoplasm worldwide. The incidence and mortality have also increased in recent decades. It is characterized by poor prognosis and a low survival rate despite sophisticated surgical and radiotherapeutic modalities. The WNTs comprise a large family of highly conserved growth factors associated with a number of functions. In this review, we focus largely on the canonical pathway, revealing the recent findings, in oral cancer research, thereby raising our understanding of the mechanisms of this crucial signaling in several cellular activities.